The Viability of Emerging Public and Private Generic Drug Infrastructure in India: An in-vitro Case Study Using Statins as Model Drug
Guru Prasanna Sahoo1, Pratikeswar Panda2, Abhijeet Mohanty3, Sudhansu Sekhar Rout4, Rajaram Mohapatra5
1Guru Prasanna Sahoo, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India.
2Pratikeswar Panda, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India.
3Abhijeet Mohanty, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India.
4Sudhansu Sekhar Rout, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India.
5Rajaram Mohapatra, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India.
Manuscript received on 30 June 2024 | Revised Manuscript received on 13 July 2024 | Manuscript Accepted on 15 August 2024 | Manuscript published on 30 August 2024 | PP: 1-8 | Volume-4 Issue-5, August 2024 | Retrieval Number: 100.1/ijapsr.E404504050824 | DOI: 10.54105/ijapsr.E4045.04050824
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© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The healthcare system has been fundamentally altered by the introduction of generic medications, and their market share continues to rise because these are genuine, dependable, secure, affordable, and accessible to all the needy and poor in society. In this regard, the generic drug industry, which strives for authenticity, affordability, and accessibility, plays a significant role. Using HMG CoA reductase inhibitors (Atorvastatin and Rosuvastatin) as model drugs, the study aimed to determine the viability of the emerging public and private generic drug infrastructure in India, which included Janaushadhi, Dava India, and other assorted companies. The organoleptic properties and official and non-official quality control tests were evaluated. According to the in-vitro dissolution profiles, the Mankind brand of atorvastatin has shown the highest dissolution profile (75.29%), and the Dava India brand of rosuvastatin has the maximum drug release (97.26%) in one hour release. The Peppas model best explained the drug release model, which inferred the release profile to be diffusion-specific. The compatibility analysis of the tablet formulation has been shown through FTIR studies. These results concluded that public generic drugs are as effective as private generic drugs, and patients can easily take the cost-effective brand of medication.
Keywords: Generic Drug, Healthcare, Atorvastatin, Rosuvastatin, Dissolution Studies, Kinetic Release
Scope of the Article: Pharmaceutical Analysis