Preparation and Characterization of Losartan Potassium Tablets
Jayanthi Bangaru1, Abhaykapse2
1Jayanthi bangaru, Department of pharmacy, Annamalai University, Annamalai Nagar Chidambaram, Tamilnadu, India.
2Abhaykapse, Department of pharmacy, Annamalai University, Annamalai Nagar Chidambaram, Tamilnadu, India.
Manuscript received on December 02, 2020. | Revised Manuscript received on December 10, 2020. | Manuscript published on December 10, 2020. | PP: 15-23 | Volume-1 Issue-1, December 2020. | Retrieval Number: A1002071120©LSP
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© The Authors. Published by Lattice Science Publication (LSP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The objective of the present study was to Preparation and characterization of losartan potassium drug. The active ingredient of losartan potassium is an angiotensin receptor blocker which works by preventing of high blood pressure (hypertension). The development of three strengths (25 mg, 50mg and 100 mg), trials were taken only for higher strength (100 mg) and optimized to get an inter convertible formula to perform the in-vitro drug release pattern from tablet and compared with the innovator sample of Cozaar tablets. Blend was evaluated for tests such as bulk density, compressibility index, LOD, tapped density, hardness ratio and sieve analysis before being punched as tablets. Tablets were tested for weight variation, thickness, hardness, friability and disintegration. the batches of LP-1 to LP-7 were taken for trails and subjected for tests. In vitro dissolution tests were performed and F1 and F2 values were calculated. Dissolution profile of LP 4 formulation was matched with innovator and F2 value was satisfactory. The formulation LP-04 has been selected as the final formula for Losartan potassium tablets (100mg), accordingly, it can be concluded that the final formulation is a robust one and the performance is less likely to be affected by the various factors studied. An excellent in vitro and in vivo correlation is expected as evident from degree of similarity found in gradient dissolution in different media and release kinetics with respect to reference listed drug product Cozaar.
Keywords: Losartan Potassium, Angiotensin Receptor Blocker, Cozaartablets , In-Vitro Drug Release.