Advancements in Pharmaceutical Science: Synthesis and Application of Molecular Cages Integrating N-Heterocyclic Carbenes for Enhanced Stability and Functionality
Nasser Thallaj
Prof. Dr. Nasser Thallaj, Pharmaceutical Chemistry and Drug Quality Control Department, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.
Manuscript received on 15 November 2024 | Revised Manuscript received on 04 December 2024 | Manuscript Accepted on 15 December 2024 | Manuscript published on 30 December 2024 | PP: 6-19 | Volume-5 Issue-1, December 2024 | Retrieval Number: 100.1/ijapsr.A406305011224 | DOI: 10.54105/ijapsr.A4063.05011224
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© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The synthesis of molecular cages to encapsulate chemical entities, such as metal ions, anions, or small molecules, has emerged as a significant area of research in supramolecular chemistry. This article explores the design and construction of various macrocyclic ligands, particularly crown ethers, cryptands, and multi-branched macrocycles, highlighting their unique structural properties and coordination chemistry with transition metals and alkali ions. We delve into the role of N-Heterocyclic Carbenes (NHCs) in enhancing the stability and functionality of these macrocyclic systems. The integration of NHCs into macrocyclic architectures presents opportunities for novel applications in catalysis, photoluminescence, and biomedical fields. By examining the advancements in macrocycle-NHC chemistry, this article underscores the potential of these systems in developing innovative materials with tailored properties for diverse applications.
Keywords: Molecular Cages; Supramolecular Chemistry; Macrocyclic Ligands; N-Heterocyclic Carbenes (NHCs); Crown Ethers; Cryptands; Coordination Chemistry; Photoluminescence.
Scope of the Article: Pharmaceutical Chemistry